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pentobarbital will minimize the level or outcome of artemether/lumefantrine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. Coadministration with powerful CYP3A4 inducers can result in lessened serum concentrations and loss of antimalarial efficacyDr Nitschke mentioned He's powerless to stop the publi